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Georgette Gafford



Curriculum Vita

Email: gafford@uwm.edu

I received my bachelor's degree from the University of Nevada and am currently pursuing a Ph.D. in the Experimental Psychology program at UWM.

My present work focuses on the role of the mammalian Target of Rapamycin (mTOR) kinase pathway in consolidation of fear memory. The mTOR kinase controls a signaling pathway activated by growth factors resulting in the translation of mRNA through its effects on the eukaryotic initiation factor 4E (eIF4E) and p70 S6 Kinase (p70 s6k). Work in our lab shows that RAP dose dependently disrupts contextual and auditory fear memory formation when infused into the amygdala immediately after training. Current experiments focus on western blot analysis with antibodies directed against total and phosphorylated p70 s6k as well as on total and phosphorylated 4E-BP1 using brain tissue from rats exposed to fear conditioning or control treatments and sacrificed at different time points after training.