Scholarly Publications

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199. "Stereochemical Control of the Pictet-Spengler Reaction in the Synthesis of Natural Products,"K. Czerwinski and J.M. Cook, in Advances in Heterocyclic Natural Product Synthesis, W. Pearson (Ed.), JAI Press, Greenwich, Vol. 3, 217-277 (1996).

200. "Synthesis and Pharmacological Properties of Novel 8-Substituted Imidazobenzo-diazepines: High Affinity, Selective Probes for α5 Containing GABA_A Receptors," R. Liu, R. Hu, P. Zhang, Phil Skolnick and J.M. Cook, J. Med. Chem., 39, 1928-1934 (1996).

201. "General Approach for the Synthesis of Macroline/Sarpagine Related Indole Alkaloids via The Asymmetric Pictet-Spengler Reaction: The Enantiospecific Synthesis of (-)- Anhydromacrosalhine-methine," T. Gan and J.M. Cook, Tetrahedron Lett., 37, 5033-5036 (1996).

202. "Partial Synthesis of The Antiamoebic Bisindole Alkaloid (-)-Macrocarpamine," T. Gan and J.M. Cook, Tetrahedron Lett., 37, 5037-5038 (1996).

203. "Benzo-fused Benzodiazepines Employed as Topological Probes for the Study of Benzodiazepine Receptor Subtypes" Qi Huang, W. Zhang, R. Liu, R. McKernan and J.M. Cook, Med. Chem. Res., 6, 384-391 (1996).

204. "Generation of Four Five-membered Rings in a One Pot Process. Studies Directed Toward The Synthesis of Dicyclopenta[a,d]pentalene via The Tadem Pauson-Khand Reaction," S. Van Ornum and J.M. Cook, Tetrahedron Lett., 37, 7185-7188 (1996).

205. "Evidence for C(1)-N(2) Bond Scission in the Isomerization of cis-N_b-Benzyl-1, 3-Disubstituted -1,2,3,4-Tetrahydro β-carbolines into Their Trans-N_b-Benzyl-1,3- Disubstituted Diastereomers Under Acidic Conditions," E.Cox, J. Li, L. Hamaker, P. Yu, and J.M. Cook, Chem. Commun., 2477-2478 (1996).

206. "Enantiospecific Formation of trans-1,3-Disubstituted Tetrahydro β-Carbolines by the Pictet-Spengler Reaction and Conversion of cis Diastereomers into their Trans Counterparts by Scission of the C1/N2 Bond," E. Cox, L. Hamaker, J. Li, P. Yu, K. Czerwinski, L. Deng, D.W. Bennett, W. Watson, M. Krawiec and J.M. Cook, J. Org. Chem., 62, 44-61 (1997).

207. "Evidence for the Conservation of Conformational Topography at Five Major GABA_A/Benzodiazepine Receptor Subsites. Potent Affinities of The (S)-Enantiomers of Framework Constrained 4,5-Substituted Pyrroloimidazobenzodiazepines," R. Liu, P. Zhang, T. Gan, R. McKernan and J.M. Cook, Med. Chem. Res., 7, 25-35 (1997).

208. "Effect of β-Carboline-3-Carboxylate-t-Butyl Ester on Ventilatory Control," H. Greenberg, M. Scharf, W. Mendelson, J.M. Cook, E. Cox and S. Scharf, Life Sci., 60, 485-492 (1997).

209. "Enantiospecific Total Synthesis of Tryprostatin A," T. Gan and J.M. Cook, Tetrahedron Lett., 38, 1301-1304 (1997).

210. "Unexpected Stereoselectivity in The Weiss-Cook Condensation of Dimethyl 1,3-Acetonedcarboxylate with 2,3-Pentanedione", R. V. Williams, V. Gadgil, A. Vig, J. Cook, G. Kubiak and Q. Huang, Perkin Trans I., 1425-1428 (1997).

211. "Mode of Action of β-Carboline Convulants on the Insect Nervous System and Their Poetential as Insecticides." J. Bloomquist, H. Ferguson, E. Cox, M. Reddy, J.M. Cook. Pesticide Science, 51, 1-6 (1997).

212. "Steric and Electronic Effects on The Weiss Reaction. Isolation of 1:1 Adducts," S. Van Ornum, G. Kubiak and J.M. Cook, Perkin Trans I., 3471-3478 (1997).

213. "Formation of Six Carbon-Carbon Bonds in a One Pot Process. Generation of the Dicyclopenta[a,e]pentalene Ring system via The Tandem Pauson-Khand Reaction," S. G. Van Ornum and J. M. Cook, Tetrahedron Lett., 38, 3657-3658 (1997).

214. "[³H]RY-080: A High Affinity, Selective Ligand for GABA_A Receptors Containing α5 Subunits," P. Skolnick, R. Hu, C. Cook, S. Hunt, J. Trometer, R. Liu, Qi Huang and J.M. Cook, J. Pharm. Exper. Thera., 283, 488-493 (1997).

215. "Synthesis of GABA_A Active Ligands by the Stille Process," T. Gan, S.G. Van Ornum and J.M. Cook, Tetrahedron Lett., 38, 8453-8456 (1997).

216. "General Approach for the Synthesis of Macroline/Sarpagine Related Indole Alkaloids via the Asymmetric Pictet-Spengler Reaction: The Enantiospecific Synthesis of the N_a-H, Azabicyclo[3.3.1]Nonane Template," P. Yu, T. Wang, F. Yu and J.M. Cook, Tetrahedron Lett., 38, 6819-6822 (1997).

217. "Regiospecific Bromination 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides," R.Liu, P. Zhang, T. Gan and J.M. Cook, J. Org. Chem., 62, 7447-7456 (1997).

218. "Diastereospecific Synthesis of Ketooxindoles. Potential Intermediates for the Synthesis of Alstonisine as well as for Voachalotine Related Oxindole Alkaloids," P. Yu and J. M. Cook, Tetrahedron Lett., 8799-8802 (1997).

219. "Conservation of Conformational Topography at Five GABA_A/Benzodiazepine Receptor Subtypes," X. He, T. Gan and J.M. Cook, NIDA Research Monograph Series, Number 178, Problems of Drug Dependence 1997: Proceedings of the 59th Annual Scientific Meeting, p. 72 (1998).

220. "Enantiospecific Total Synthesis of (-)-Anhydromacrosalhine-methine and Partial Synthesis of the Antiamoebic Bisindole Alkaloid, (-)-Macrocarpamine," T. Gan and J.M. Cook, J. Org. Chem., 63, 1478-1483 (1998).

221. "Synthesis and Evaluation of Analogues of the Partial Agonist 6-(Propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic Acid Ethyl Ester (6-PBC) & the Full Agonist 6-(Benzyloxy)-4-(methoxymethyl)--carboline-3- carboxylic Acid Ethyl Ester (ZK-93423) at BzR sites" Eric D. Cox, Hernando Diaz-Arauzo, Q. Huang, M. Reddy, B. Harris, R. McKernan, P. Skolnick, and J.M. Cook. J. Med. Chem., 41, 2537-2552 (1998).

222. "GABA_A - Benzodiazepine Receptors in the Striatum Are involved in the Sedation Produced by a Moderate, but Not an Intoxicating Ethanol Dose in Outbred Wistar Rats," H. June, S. H. Chen, G. Cheatem, R. Liu, T. Gan and J.M. Cook. Brain Research, 794, 103-118 (1998).

223. "Enantiospecific Total Synthesis of (+)-Ajmaline and Alkaloid G via the Asymmetric Pictet-Spengler Reaction," J. Li and J.M. Cook, J. Org. Chem., 63, 4166-4167 (1998).

224. "Enantiospecific Synthesis of Optically Active 6-Methoxytryptophan Derivatives and Total Synthesis of Tryprostatin A," T. Gan, R. Liu, P. Yu., S. Zhao and J.M. Cook, J. Org. Chem., 62, 9298-9304 (1998).

225. "Predictive Models for GABA_A/Benzodiazepine Receptor Subtypes: Studies of Quantitative Structure-Activity Relationships (QSAR) for Imidazobenzodiazepines at Five Recombinant GABA_A/BzR Subtypes [αxβ3γ2(x=1-3,5,6] via CoMFA," Q. Huang, R. Liu, P. Zhang, R. McKernan, D. Bennett, T. Gan, X. He and J.M. Cook, J. Med. Chem., 41, 4130-4142 (1998).

226. "The Enantiospecific Total Synthesis of Norsuaveoline," T. Wang, P. Yu, J. Li and J.M. Cook, Tetrahedron Lett., 39, 8009-8012 (1998).

227. "Total Synthesis of Trypostatin A and B as Well as Their Enantiomers," S. Zhao, T. Gan, Peng Yu and J.M. Cook, Tetrahedron Lett., 39, 7009-7012 (1998).

228. "The Livinghouse Catalytic Approach to the Tandem Pauson-Khand Reaction. Entry into the Parent Ring Systems of Dicyclopenta[a,f]pentalene and Dicyclopenta[a,e]pentalene, S. Van Ornum, M. Bruendl and J.M. Cook, Tetrahedron Lett., 39, 6649-6650 (1998).

229. "Identification of Quinine Metabolites in Urine After Oral Dosing in Humans," P. Bannon, P. Yu, J. M. Cook, L. Roy and J-P. Villeneuveo, J. Chromatography B, Biomedical Science and Applications, 715, 387-393 (1998).

230. "Enantiospecific Total Synthesis of the Sarpagine Related Indole Alkaloids Talpinine and Talcarpine. The Oxyanion Cope Approach." P. Yu and J.M. Cook, J. Org. Chem., 63, 9160-9161 (1999).

231. "General Approach for the Synthesis of Ajmaline/ Sarpagine Indole Alkaloids. Enantiospecific Total Synthesis of (+) Ajmaline, Alkaloid G, and Novsuaveoline via the Asymmetric Pictet-Spengler Reaction," J. Li, T. Wang, P. Yu, A. Peterson, D. Soerens, R. Weber, D. Grubisha, D. Bennett, and J. M. Cook, J Am. Chem. Soc., 121, 6998-7010 (1999).

232. "Studies of Molecular Pharmacophore/Receptor Models for GABA_A/Benzodiazepine Receptor Subtypes: Binding Affinities of Substituted β-Carbolines at Recombinant αxβ3γ2 Subtypes and Quantitative Structure-Activity Relationship Studies via a Comparative Molecular Field Analysis," Q. Huang, E. Cox, T. Gan, C. Ma, D. Bennett, Ruth McKernan and James M. Cook, Drug Des. Disc., 16, 55-76, (1999).

233. "Concise Synthesis of Optically Active Ring-A Substituted Tryptophans," C. Ma., X. Liu, S. Yu, S. Zhao and J.M. Cook, Tetrahedron Lett., 40, 657-660 (1999).

234. "Exploration of Regions L₂ and LD₁ of Pharmacophore/Receptor Models for GABA_A/ BzR Subtypes, Problems of Drug Dependence, 1998: Proceedings of the 60th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc., ed. Louis Harris, NIDA Research Monograph, 179, 303 (1999).

235. "Extension of the Tandem Pauson-Khand Reaction to [5.6.6.5]Tetracycles: A Unique Entry into cis-Fused Decalins," M. Bruendl, S. Van Ornum, Tze-Ming Chan and J.M. Cook, Tetrahedron Lett., 40, 1113-1116 (1999).

236. "Studies in the Search for α5 Subtype Selective Agonists for GABA_A/BzR Sites," S. Yu, C. Ma, X. He, R. McKernan, and J.M. Cook, Med. Chem. Res., 9, 71-88 (1999).

237. "Studies in Search of α2 Selective Ligands for GABA_A/BzR Receptor Subtypes. Part 1. Evidence for the Conservation of Pharmacophoric Descriptors for DS Subtypes," S. Yu, X. He, C. Ma, R. McKernan , and J.M. Cook, Med. Chem. Res., 9, 186-202, (1999).

238. "Studies of Molecular Pharmacophore/Receptor Models for GABA_A/BzR Subtypes: Binding Affinities of Symmetrically Substituted Pyrazolo[4,3-c]quinolin-3-ones at Recombinant αxβ3γ2 Subtypes and Quantitative Structure-Activity Relationship Studies via Comparative Molecular Field Analysis," X. He, Q. Huang, S.Yu, C. Ma, R. McKernan, and J.M. Cook, Drug Des. Disc., 16, 77-91, (1999).

239. "Effect of the Leaving Group on Alkylation Diastereoselectivity of the Schöllkopf Chiral Auxillary," C. Ma, X. He, X. Liu, S. Yu, S. Zhao, and J.M. Cook, Tetrahedron Lett., 40, 2917-2918 (1999).

240. "Pharmacophore/Receptor Models for GABA_A/BzR Subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) via a Comprehensive Ligand-Mapping Approach," Qi Huang, X. He, C. Ma, R. Liu, S. Yu, R. McKernan, G. Wenger, C. Dayer, and J. M.Cook, J. Med. Chem., 43, 71-95 (2000).

241. "Efficient Asymmetric Synthesis of Important Tryptophan Analogues for Biological Research via the Schöllkopf Chiral Auxillary," C. Ma, S. Yu, X. He, X. Liu, and J.M. Cook, Tetrahedron Lett., 41, 2781-2785 (2000).

242. "Enantiospecific Total Synthesis of the Sarpagine Related Indole Alkaloids Talpinine and Talcarpine, as well as the Improved Total Synthesis of Alstonerine and Anhydromacrosalhine-methine via the Asymmetric Pictet-Spengler Reaction," P. Yu, T. Wang, J. Li, and J.M. Cook, J. Org. Chem., 65, 3173-3191 (2000).

243. "Pharmacophore/Receptor Models for GABA_A/BzR α2β3γ2, α3β3γ2, α4β3γ2 Recombinant Subtypes. Included Volume Analysis and Comparison to α1β3γ2, α5β3γ2 and α6β3γ2 Subtypes," X. He, Q. Huang, C. Ma, S. Yu, R. McKernan, and J.M. Cook, Drug Des. Disc., 17, 131-171 (2000).

244. "General Approach for the Synthesis of Sarpagine/Ajmaline Indole Alkaloids. Stereospecific Total Synthesis of the Sarpagine Alkaloid (+)-Vellosimine," T. Wang and J.M. Cook, Org. Letters, 2, 2057-2059 (2000).

245. "The Molybdenum-Mediated Tandem Pauson-Khand Reaction. High Yield Entry into [5.5.5.5] Tetracyclic Systems," H. Cao, S.G. Van Ornum, and J.M. Cook, Tetrahedron Lett., 41, 5313-5316 (2000).

246. "Utility of the Tandem Pauson-Khand Reaction in the Construction of Tetracycles," S. Van Ornum, M. Bruendel, H. Cao, M. Reddy, D. Grubisha, D. Bennett, and J.M. Cook, J. Org. Chem., 65, 1957-1971 (2000).

247. "General Approach for the Synthesis of Indole Alkaloids via the Asymmetric Pictet- Spengler Reaction. First Enantiospectific Total Synthesis of (-)-Corynantheidine as well as the Enantiospecific Total Synthesis of (-)-Corynantheidol (-)-Geissoschizol, and (+)-Geissoschizine," S. Yu, M. Berner, and J.M. Cook, J. Am. Chem. Soc., 122, 7827-7828 (2000).

248. "Enantiospecific Total Synthesis of the Enantiomer of the Indole Alkaloid Affinisine," X. Liu, T. Wang, Q. Xu, C. Ma, and J.M. Cook, Tetrahedron Lett., 41, 6299-6303 (2000).

249. "Determinants of Recognition of Ligands Binding to Benzodiazepine Receptor/GABA_A Receptors Initiating Sedation," D.L. Harris, T.M. DeLorey, X. He, J.M. Cook, and G.H. Loew, Eur. J. Pharmacol., 401, 271-287 (2000).

250. " A Single Amino Acid Residue on the α5 Subunit (Ile215) Is Essential for Ligand Selectivity at α5β3γ2 GABA_A Receptors," M. Strakhova, S. Harvey, C. Cook, J.M. Cook, and P. Skolnick, Mol. Pharmacol, 58, 1434-1440 (2000).

251. "Simultaneous Determination of Quinine and Four Metabolites in Plasma and Urine Using High Performance Liquid Chromatography," Rajaa Mirghani, Orjan Ericsson, J. Cook, P. Yu, and Lars Gustafsson, J. of Chromatography, B., 754(1), 57-64 (2001).

252. "Stereocontrolled Total Synthesis of Alkaloid G via the Oxy-anion Cope Rearrangement and Improved Total Synthesis of (+)-Ajmaline," T. Wang, Q. Xu, P. Yu, X. Liu, and J.M. Cook, Org. Lett., 3(3), 345-348 (2001).

253. "Stereocontrolled Conversion of Quinine into 10(R), 11 Dihydroxydihyroquinine via the Sharpless Osmylation Process," T. Zheng, Judy Flippen-Anderson, T. Wang, P. Yu, R. Mirghani, and J.M. Cook, J. Org. Chem., 66, 1509-1511 (2001).

254. "Efficient Asymmetric Synthesis of Biologically Important Tryptophan Analogues via a Palladium Heteroannulation Reaction," C. Ma, X. Liu, X. Li, J. Flippen-Anderson, S.Yu, and J.M. Cook, J. Org. Chem., 66, 4525-4542 (2001).

255. "Model of the BzR Binding Site: Correlation of Data From Site-Directed Mutagenesis and the Pharmacophore/Receptor Model," X. He, C. Zhang, and J.M. Cook, Med. Chem. Res., 10, 269-308 (2001).

256. "GABA_A-Receptors Containing α5 Subunits In the CA1 and CA3 Hippocampal Fields Regulate Ethanol-Motivated Behaviors: An Extended Ethanol Reward Circuitry," H. June, P. Mc Kay, S. Harvey, K. Foster, M. Garcia, D. Mason, R.Cummings, C. Grey, S. Mc Cane, L. Williams, T. Johnson, X. He, S. Rock, and J.M. Cook, J. Neurosci., 21, 2166-2177 (2001).

257. "Zolpidem, Triazolam and Diazepam Decrease Distress Vocalizations in Mouse Pups: Differential Antagonism by Flumazenil and β-Carboline-3-carboxylate-t-butyl Ester (βCCt)," J. Rowlett, W. Tornatzky, J.M. Cook, C. Ma, and K. Miczek, J. Pharmacol. Exp. Ther., 297, 247-253 (2001).

258. "Different Types of GABA_A Receptors May Mediate the Anticonflict and Response Rate-decreasing Effects of Zaleplon, Zolpidem and Midazolam in Squirrel Monkeys," C. Parnois, E. Cox, J.M. Cook, and J. Bergman, Psychopharmacology, 156, 461-468, (2001).

259. "Influence of Benzodiazepine Binding Site Ligands on Fear-Conditioned Contextual Memory," T. M. DeLorey, R. Lin, B. McBrady, X. He, J. M. Cook, J.Lameh, G. Loew, Eur. J. Pharmacol., 426, 45-54 (2001).

260. "Differential Sensitivity to Inverse Agonists of GABA_A/benzodiazepine Receptors in Rats with Genetic Absence-Epilepsy," M. Vergnes, A. Boehler, X. He, H. Greney, M. Dontenwill, J.M. Cook, and C. Marescauk, Epilepsy Res., 47, 43-53, (2001).

261. "Differential Role of GABA_A/Benzodiazepine Receptors Containing α1 and α5 Subunits in the Discriminative Stimulus Effects of Triazolam in Squirrel Monkeys," S. Lelas, J. Rowlett, R. Spealman, J. Cook, C. Ma, X. Li, and W. Yin, Psychopharmacology, 161, 180-188 (2002).

262. "Enantiospecific, Stereospecific Total Synthesis of (+)-Majvinine, (+)-10-Methoxyaffinisine and (+)-N_a-Methylsarpagine as well as the Total Synthesis of the Alstonia Bisindole Macralstonidine," S. Zhao, X. Liao, and J.M. Cook, Org. Lett., 4, 687-690 (2002).

263. "Selective Antagonism of the Ataxic Effects of Zolpidem and Triazolam by the GABA_A/α1- Preferring Antagonist β-CCt in Squirrel Monkeys," D. Platt, J. Rowlett, R. Spealman, J.M. Cook and Chunrong Ma, Psychopharmacology, 164, 151-159 (2002).

264. "General Approach for the Synthesis of Sarpagine/Macroline Indole Alkaloids. Enantiospecific Total Synthesis of the Indole Alkaloid Trinervine," Xiaoxiang Liu and James M. Cook, Org. Lett., 3, 4023-4026 (2002).

265. "Enantiospecific Total Synthesis of the Enantiomer of the Indole Alkaloid Intermediate Macroline," Xiaoxiang Liu, Chunchun Zhang, Xuebin Liao, and James M. Cook, Tetrahedron Letters, 43, 7373-7377 (2002).

266. "Discriminative Stimulus Effects of Benzodiazepine (BZ)1 Receptor-selective Ligands in Rhesus Monkeys," L.R. McMahon,L.R. Gerak, L. Carter, C. Ma, J.M. Cook, and C.P. France, J. Pharmacol. Exp. Ther., 300, 505-512, (2002).

267. "Biological Activity of the Tryprostatins," S. Zhao, K. Smith, A. Deveau, C. Dieckhaus, M. Johnson, T.L. McDonald, and J.M. Cook, J. Med. Chem., 45, 1559-1562 (2002).

268. "The GABA_A Receptor α1 Subtype in the Ventral Pallidum Regulates Alcohol-Seeking Behaviors," S. Harvey,, K. Foster,P. McKay, M. Carroll, R. Seyoum, J.E. Woods II, C. Grey, C. Jones S. McCane, R. Cummings, D. Mason, C. Ma, J.M. Cook, and H. June, J. Neuroscience, 22, 3765-3775 (2002).

269. "Effects of Hippocampal Injections of a Novel Ligand Selective for the α5β2γ2 Subunits of the GABA/Benzodiazepine Receptor on Pavlovian Conditioning," D.Bailey, J. Tetzlaff, J.M. Cook, X. He, and F. Helmstetter, Neurobiology of Learning and Memory, 58, 1-10 (2002).

270. "Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway," R.A. Mirghani, U. Yasar, T. Zheng, J.M. Cook, L.L. Gustafsson, G. Tybring, and O. Ericsson, Drug Metab. Dispos., 30, 1368-1371 (2002).

271. "The Enantiospecific, Stereospecific Total Synthesis of the Oxindole Alkaloid Alstonisine," X.Z. Wearing and J.M. Cook, Org. Lett., 4, 4237-4240 (2002).

272. "Regiospecific, Enantiospecific Total Synthesis of the Alkoxy-Substituted Indole Bases, 16-epi-N_a-Methygardneral, 11-Methoxyaffinisine, and 11-Methoxymacroline as Well as the Indole Alkaloids Alstophylline and Macralstonine," Xiaoxiang Liu and James M. Cook, Org. Lett., 4, 3339-3342 (2002).

273. "Stereospecific Enantiospecific Total Synthesis of the Sarpagine Indole Alkaloids (E)16-Epiaffinisine, E(16)-Epinormacusine B and Dehydro-16-epiaffinisine," J.Yu, X. Liao, and J.M. Cook, Org. Letters, 4, 4681-4684 (2002).

274. "General Approach for the Total Synthesis of the Sarpagine-related Indole Alkaloids(+)-N_a-Methyl-16-Epipericyclivine, (-)-Alkaloid Q3 and (-)-Panarine via the Asymmetric Pictet-Spengler Reaction," Jianming Yu, Xiangyu Wearing, and James M. Cook, Tetrahedron Lett., 44, 543-547 (2003).

275. "Discriminative Stimulus Effects of a High Dose of Zolpidem in Squirrel Monkeys: Evidence for a Primary Role of GABA_A/α1 Receptors," J.K Rowlett, R. Spealman, S. Lelas, J.M. Cook, and W. Yin, Psychopharmacology, 165, 209-215 (2003).

276. "The Enantiospecific, Stereospecific Total Synthesis of the Ring-A Oxygenated Sarpagine Indole Alkaloids (+)-Majvinine, (+)-10-Methoxyaffinisine and (+)-N_a-Methylsarpagine as well as the First Total Synthesis of the Alstonia Bisindole Alkaloid Macralstonidine," S. Zhao, X. Liao, T. Wang, J. Flippen-Anderson , and J.M. Cook, J. Org. Chem., 68, 6279-6295 (2003).

277. "The Reinforcing Properties of Alcohol are Mediated By GABA_(A1) Receptors in the Ventral Pallidum," H. June. K. Foster, P. McKay, M. Carroll, J. E. Woods II, Scott C. Harvey, Regat Seyoum, William J. H. Eiler II, Collette Grey, Shannon McCane, Cecily Jones, W. Yin, D. Mason, R. Cummings, M. Garcia, C. Ma, P.V.V.S. Sarma, James M. Cook, and P. Skolnick, Neuropsychopharmacology, 28, 2124-2137 (2003).

278. "The Synthesis of a Dicyclopenta[a,e]pentalene via a Molybdenum Hexacarbonyl-Mediated Tandem Allenic Pauson-Khand Reaction," H. Cao, J. Flippen-Anderson, and J.M. Cook, J. Am. Chem. Soc., 125, 3230-3231 (2003).

279. "Studies on the Rh and Ir-Mediated Tandem Pauson-Khand Reaction. A New Entry into the Dicyclopenta [a,d] cyclooctene Ring System," H. Cao, S. R. Mundla, and J.M. Cook, Tetrahedron Lett., 44, 6165-6168 (2003).

280. "General Approach for the Synthesis of Sarpagine Indole Alkaloids. Enantiospecific Total Synthesis of (+)-Vellosimine, (+)-Normacusine B, (-)-Alkaloid Q3, (-)-Panarine, (+)-N_a-Methylvellosimine, and (+)N_a-Methyl-16-epipericyclivine, J. Yu, T. Wang, X. Liu, J. Deschamps, J. Flippen-Anderson, X. Liao, and J.M. Cook, J. Org. Chem., 68, 7565-7581 (2003).

281. " Studies in Search of Diazepam-Insensitive Subtype Selective Agents for GABA_A/Bz Receptors," X. Li, C. Ma, X. He, J. Yu, D. Han, C. Zhang, J. Atack, and J.M. Cook, Med. Chem. Res., 9, 504-537 (2003).

282. "The First Enantiospecific Synthesis of (-)-Koumidine via the Intramolecular Palladium-catalyed Enolate Driven Cross Coupling Reaction. The Stereospecific Introduction of the 19-(Z) Ethylidene Side Chain," Hui Cao, Jianming Yu, Xiangyu Z. Wearing, Chunchun Zhang, Xiaoxiang Lui, Jeffery Deschamps, and James M. Cook, Tetrahedron Lett., 44, 8013-8017, (2003).

283. "Synthesis, in Vitro Affinity, and Efficacy of a Bis 8-Ethynyl-4H-imidazo[1,5a]-[1,4]benzodiazepine Analogue, the First Bivalent α5 Subtype Selective BzR/GABA_A Antagonist", Xiaoyan Li, Hui Cao, Chunchun Zhang, Roman Furtmueller, Karoline Fuchs, Sigismund Huck, Werner Sieghart, Jeffrey Deschamps, and James M. Cook, J. Med. Chem., 46, 5567-5570 (2003).

284. "Enantiospecific Total Synthesis of (-)-(E)-Epiaffinisine, (+)-E(16)-Epinormacusine B, and (+)-Dehydro-16-epiaffinisine as well as the Stereocontrolled Total Synthesis of Alkaloid G," J. Yu, T. Wang, X. Wearing, J. Ma, and James M. Cook, J. Org. Chem., 68, 5852-5859 (2003).

285. "Regiospecific, Enantiospecific Total Synthesis of the 12-Alkoxy-Substituted Indole Alkaloids, (+)-12-Methoxy-N_a-methylvellosimine, (+)-12-Methoxyaffinisine, and (-)-Fuchsiaefoline", Hao Zhou, Xuebin Liao, and James M. Cook, Org. Lett., 6, 249-252, (2004).

286. "GABA_A and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors," K. Foster, P. McKay, R. Seyoum, D. Milbourne, W. Yin, P.V.V.S. Sarma, J.M. Cook, and H. June, Neuropsychopharmacology, 29, 269-284 (2004).

287. "Stereocontrolled Total Synthesis of (-)-Vincamajinine and (-)-11-Methoxy-17-epivin-camajine," Jianming Yu, Xiangyu Wearing, and J.M. Cook, J. Am. Chem. Soc., 126, 1358-1359 (2004).

288. "RY 023: A Selective High Affinity Ligand for GABA(A)-Receptor Containing α5 Subunit Attenuates Ethanol-Maintained Responding Following Systemic and Microinjection Into the CA1 and CA3 Hippocampal Fields," S. Harvey, K. Foster, P. Mc Kay, M. Garcia, D. Mason, R. Cummings, C. Grey, S. McCane, X. He, J.M. Cook, and H.L. June, submitted.

289. "ABCG2 Expression, Function, and Promoter Methylation in Human Multiple Myeloma," J. Turner, J. Gump, C. Shang, J.M. Cook, D. Marchion, L.Hazlehurst, P. Munster, M. Schell, W. Dalton, and D. Sullivan, Blood, 108, 3881-3889 (2006).

290. "GABA_A/α1 Receptor Agonists and Antagonists: Effects on Species-typical and Heightened Aggressive Behavior After Alcohol Self-Administration in Mice," R. Almeida, J.K. Rowlett, J.M. Cook, W. Yin, and K. Miczek, Psychopharmacology, 172, 255-263 (2004).

291. "A High Affinity Ligand for GABA(A)-Receptor Containing α5 Subunit Antagonizes Ethanols Neurobehavioral Effects in Long-Evans Rats,", P. McKay, K. Foster, D. Mason, R. Cummings, M. Garcia, L. Williams, C. Grey, S. McCane, X. He, J.M. Cook and H.L. June, Psychopharmacology, 172, 455-462 (2004).

292. "Benzodiazepines and Heightened Aggressive Behavior in Rats: Reduction by GABA_A/α1 Receptor Antagonists," S. Gourley, J.Debold, W. Yin, J. Cook, and K. Miczek, Psychopharmacology, 178, 232-240 (2005).

293. "Determination of the Stable Conformation of GABA(A)-Benzodiazepine Receptor Bivalent Ligands by Low Temperature NMR and X-ray Analysis," D. Han, F.H. Försterling, X. Li, J. Deschamps, H. Cao and J.M. Cook, Bioorg. Med. Chem. Lett., 14, 1465-1469 (2004).

294. "The First Enantiospecific Total Synthesis of a C-quaternary Voachalotine Alkaloid, (+)-Dehydrovoachatoline," J. Yu, A. Wearing, and J.M. Cook, Tetrahedron Lett., 45, 3937-3940 (2004).

295. "Bartoli Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 100-103 (2004).

296. "Batcho-Leimgruber Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li; J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 104-109 (2004).

297. "Fischer Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 116-127 (2004).

298. "Gassman Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 128-131 (2004).

299. "Graebe-Ullmann Carbazole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 132-134 (2004).

300. "Madelung Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 140-144 (2004).

301. "Nenitzescu Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 144-153 (2004).

302. "Reissert Indole Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 154-158 (2004).

303. "Pinner Pyrimidine Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 534-537 (2004).

304. "Von Richter Cinnoline Synthesis, in Name Reactions in Heterocyclic Chemistry" J. Li, J. M. Cook; J. J. Li, Ed.; John Wiley & Sons: Hoboken, NJ, pp. 538-540 (2004).

305. "Bidirectional Effects of Benzodiazepine Binding Site Ligands in the Elevated Plus Maze: Differential Antagonism by Flumazenil and βCCt," M. Savic, D. Obradovic, N. Ugrešic, J.M. Cook, W. Yin and D. Bokonjic, Pharmacol. Biochem. Behav., 79, 279-290 (2004).

306. "Development of Selective Ligands for Benzodiazepine Receptor Subtypes by Manipulating the Substituents at Positions -3 and -7 of Optically Active BzR Ligands," X. Li, J. Yu, J. Atack, and J.M. Cook, Med. Chem. Res., 13, 259-281 (2004)

307. "Synthesis of Optically Active Ring-A Substituted Tryptophans as IDO Inhibitors," X. Li, W. Yin, P.V.V. S. Sarma, H. Zhao, J. Ma and J. M. Cook, Tetrahedron Lett., 45, 8569-8573 (2004).

308. "The Synthesis of Dicyclopenta[a,e]pentalenes via a Molybdenum Carbonyl-Mediated Tandem Allenic Pauson-Khand Reaction and the X-ray Crystal Structure of a Planar Dicyclopenta[a,e]pentalene," H. Cao, S. Van Ornum, J. Deschamps, J. Flippen-Anderson, F. Laib, J.M. Cook, J. Am. Chem. Soc., 127, 933-943 (2005).

309. "Conformational Analysis in the Asymmetric Pictet-Spengler Reaction, Evidence for the C(1)-N(2) Scission Process in the Cis to Trans Isomerization" D. Han, F. H. Försterling, J. Deschamps, D. Parrish, X. Liu, S.Huang, W. Yin, and J.M. Cook, J. Nat. Prod., 70, 75-82 (2007).

310. "Bidirectional Effects of Benzodiazepine Binding Site Ligands in the Passive Avoidance Task: Differential Antagonism by Flumazenil and &betea;CCt," M. Savic, D. Obradovic, N. Ugresic, J.M. Cook, W. Yin and D. Bokonjic, Behavioral Brain Res., 158, 293-300 (2005).

311. "A General Strategy for the Synthesis of Vincamajine-related Indole Alkaloids: Stereocontrolled Total Synthesis of (+)-Dehydrovoachalotine, (-)-Vincamajinine and (-)-11-Methoxy-17-epivincamajine, as well as the Related Alcohols, Quebrachidinediol, Vincamajinediol and Vincarinol," J. Yu, A. Wearing and J. M. Cook, J. Org. Chem., 70, 3963-3979 (2005).

312. "Bidirectional Effects of Benzodiazepine Binding Site Ligands in the Active Avoidance Acquisition and Retention: Differential Antagonism by Flumazenil and &betea;CCt," M. Savic, D. Obradovic, N. Ugrešic, J.M. Cook, P.V.V.S. Sarma and D. Bokonjic, Psychopharm., 180, 455-465 (2005).

313. "Benzodiazepines and Heightened Aggressive Behavior in Rats: Reduction by GABA(A)/alpha(1) Receptor Antagonists," S. L. Gourley, J. F. DeBold, W. Y. Yin, J. M. Cook, K. A. Miczek, Psychopharm., 178, 232-240 (2005).

314. "Contribution of α1GABA_A and α5GABA_A Receptor Subtypes to the Discriminative Stimulus Effects of Ethanol in Squirrel Monkeys" D. Platt, A. Duggan, R. Spealman, J.M. Cook, X. Li, W. Yin and J. K. Rowlett, J. Pharm. Exp. Therapeut., 313, 658-667 (2005).

315. "Contribution of GABA_A Receptor Subtypes to the Anxiolytic-Like, Motor, and Discriminative Stimulus Effects of Benzodiazepines: Studies with the Functionally Selective Ligand SL651498 [6-Fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]" S. Licata, D. Platt, J.M. Cook, P.V.V.S. Sarma, G. Griebel and J. Rowlett, J. Pharm. Exp. Therapeut., 313, 1118-1125 (2005).

316. "First Regiospecific, Enantiospecific Total Synthesis of Gardnerine and Gardnutine" H. Zhou, P.V.V.S. Sarma, D. Han, J. Deschamps and J. M. Cook, Tetrahedron Lett., 46, 4219-4224 (2005).

317. "Confirmation of the Structure of (3S)-3-Hydroxyquinine: Synthesis and X-ray Crystal Structure of Its 9-Aceto Analogue" P.V.V.S. Sarma, D. Han, J. Deschamps and J. M. Cook, J. Nat. Prod., 68, 942-944 (2005).

318. "Selective Antagonism of GABA_A Receptor Subtypes: An In Vivo Approach to Exploring the Thereapeutic and Side Effects of Benzodiazepine-Type Drugs," J.K. Rowlett, J. M. Cook, A.N. Duke, D. M. Platt. CNS Spectr., 10, 40-48 (2005).

319. "Synthesis of Bivalent Ligands of β-Carboline-3-Carboxylates Via a Palladium-Catalyzed Homocoupling Process" W. Yin, P.V.V.S. Sarma, J. Ma, D. Han, J. L. Chen and J. M. Cook, Tetrahedron Lett., 46, 6363-6368 (2005).

320. "The First Regiospecific, Enantiospecific Total Synthesis of 6-Oxoalstophylline and and Improved Total Synthesis of Alstonerine and Alstophylline as Well as the Bisindole Alkaloid Macralstonine" X. Liao, H. Zhou, X. Z. Wearing, J. Ma and J. M. Cook, Org. Lett., 7, 3501-3504 (2005).

321. "Selective GABA_A α5 Benzodiazepine Inverse Agonist Antagonizes the Neurobehavioral Actions of Alcohol" J. B. Cook, K. L. Foster, W. J. A. Eiler II, P. F. McKay, J. Woods II, S. C. Harvey, M. Garcia, C. Grey, S. McCane, D. Mason, R. Cummings, X. Li, J. M. Cook and H. June, Alcohol Clin. Exp. Res., 29, 1390-1401 (2005).

322. "ABCG2 Expression, Function and Promoter Methylation in Human Multiple Myeloma," J. G. Turner, J. L. Gump, C. C. Zhang, J. M. Cook, D. Marachion, L. Hazelhurst, P. Munster, M. J. Schell, W. S. Dalton and D. M. Sullivan, Blood, 108, 3881-3889 (2006).

323. "Antiseizure Activity of Novel GABA(A) Receptor Subtype Selective Benzodiazepine Analogs in Mice and Rat Models," F. Rivas, J. Stables, L. Murphee, R. Edwanker, C. Sawant, S. Huang, H. Zhou, R. Furtmueller, W. Sieghart, and J. M. Cook, J. Med. Chem., in preparation.

324. "An Updated Unified Pharmacophore Model of the Benzodiazepine Binding Site on &gamma - Aminobutyric Acid_A Receptors: Correlation with Comparative Models," T. Clayton, J. Chen, M. Ernst, L.Richter, B.A. Cromer, C.J. Morton, H.Ng, C. Cook - Kaczorowski, F.J. Helmstetter, R. Furtmüeller, G. Ecker, M.W. Parker, W. Sieghart and J.M. Cook, Curr. Med. Chem., 14, 2755-2775 (2007).

325. "General Approach for the Synthesis of 12-Methoxy-substituted Sarpagine Indole Alkaloids Including (-)-12-Methoxy-N_b-methylvoachalotine, (+)-12-Methoxy-N_a-methylvellosimine, (+)-12-Methoxyaffinisine and (-)-Fuchsiaefoline," H. Zhao, X. Liao, W. Yin, J. Ma and J. M. Cook, J. Org. Chem., 71, 251-259 (2006).

326. "An Improved Total Synthesis of (+)- Macroline and Alstonerine as Well as the Formal Total Synthesis of (-)- Talcarpine and (-)-Anhydromacrosalhine-methine," X. Liao, H. Zhou, J. Yu, and J. M. Cook, J. Org. Chem., 71, 8884-8890 (2006).

327. "Enhanced Sucrose Pellet Consumption Induced by Benzodiazepine-Type Drugs in Squirrel Monkeys: Role of GABA(A) Receptor Subtypes," A. Duke, D. Platt, J. M. Cook, S. Huang, W. Yin, B. Mattingly, and J. K. Rowlett, Psychopharmacol. (Berlin), 187, 321-330 (2006).

328. "Enantiospecific Synthesis of (+)-N_a-Methyl-pericyclivine and (-)-N_a-Methylakuammidine as well as the Ring-A Oxygenated Natural Products, (+)-10-Methoxy-N_a-Methylpericyclivine and 10-Hydroxy-N_a-Methylpericyclivine," Org. Lett., 8, 1017-1020 (2006).

329. "Benzodiazepine Site Inverse Agonists and Locomotor Activity in Rats: Bimodal and Biphasic Influence," M. Savic, D. Obradovio, N. Ugresic, J. M. Cook, W. Yin, M. Van Linn and D. R. Bonkonjic, Pharmacol. Biochem. Behav., 84, 35-42 (2006).

330. "Conformational Analysis of the Cis and Trans Adducts of the Pictet-Spengler Reaction. Evidence for the Structural Basis for the C(1)-N(2) Scission Process in the Cis to Trans Isomerization," D. Han, F. Forsterling, J. Deschamps, D. Parrish, X. Liu, W. Yin, S. Huang and J. M. Cook, J. Nat. Prod. (Lloydia), 70, 75-82 (2007).

331. "Are GABA_A Receptors Containing α5 Subunits Contributing to the Sedative Properties of α5 Agonists?" M. Savic, S. Huang, R. Furtmueller, T. Clayton, S. Huck, D. Obradovic, N. Ugresic, W. Sieghart, D. Bokonjic and J. M. Cook, Neuropsychopharmacology, 32, 1-8, (2007).

332. "Synthesis and Structure Activity Relationships of Tryprostatin A: An Inhibitor of Breast Cancer Resistant Protein," H. Jain, C. Zhang, S. Zhao, H. Zhou, Amy Deveau, C. Dieckhaus, M. Johnson, K. Smith, T. MacDonald, H. Kakeya, H. Osada and J.M. Cook, Bioorg. and Med. Chem., 00, 000-000 (2008).

333. "The First Enantiospecific Total Synthesis of the Important Biogenetic Intermediates, (+)- Polyneuridine and (+)-Polyneuridine Aldehyde, as well as 16-Epi-vellosimine and Macusine-A," W. Yin, J. Ma, F. Rivas and J. M. Cook, Org. Lett., 9, 295-298 (2007).

334. "Dopamine and Benzodiazepine-Dependent Mechanisms Regulate the EtOH-Enhanced Locomotor Stimulation in the GABA_A α1 Subunit Null Mutant Mice," H. L. June Sr., K. L. Foster, W. J.A. Eiler, J. Goergen, J. B. Cook, N. Johnson, B. Mensah-Zoe, J. O. Simmons, H. L. June Jr., W. Yin, J. M. Cook, and G. E. Homanics, Neuropsychopharmacology, 32, 137-152 (2007).

335. "An Efficient Palladium Catalyzed Negishi Cross-Coupling Reaction with Aryvinyl Iodides: Facile Regioselective Synthesis of E-Stilbenes and their Analogues," M. Shahjahan Kabir, A. Monte and J. M. Cook, Tetrahdron Lett., 48, 7269-7273 (2007).

336. "Total Synthesis of the Opioid Agonistic Indole Alkaloid, Mitragynine, as well as the First Total Synthesis of 9- Methoxygeissoschizol and 9-Methoxy-N_b-methyl-geissoschizol," Jun Ma, W. Yin, H. Zhou and J.M. Cook, Org. Lett., 9, 3491-3494 (2007).

337. "Cascade Approach toward the Core Structure of Neosarpagine," X. Liao, S. Huang, D. Parrish and J.M. Cook, Org. Lett., 9, 1469-1471 (2007).

338. "GABA_A Receptors Containing α5 Subunits: A Substrate for Memory Modulation," M. Savic, T. Clayton. R. Furtmueller, I. Gaurilovic, J. Samardzic, S. Savic, W.Sieghart and J.M. Cook, Brain Res., 00, 0000 (2008).

339. "Contribution of α1 Subunit - containing γ-Amino-butyric Acid (A) Receptors to Benzodiazepine - Induced Ataxia and Myorelaxation in Squirrel Monkeys," S.Licata, D. Platt, J. Cook, M. Van Linn, and J. Rowlett, Psychopharmacology, 00, 0000 (2008).

340. "Computational Assesment of Benzodiazepine Influence on Contextual Memory," D. Harris, T. Clayton, J. Cook, R.Halliwell, P. Sahbaie, W. Sieghart, R. Furtmueller, and T. DeLorey, J. Med. Chem., 00, 0000 (2008).

341. "The Syntheisis of the Macroline Alkaloids: A Recent Review," C.S. Edwanker, R. Edwanker, S. Rallapalli, and J.M. Cook, Nat. Prod. Reports, 00, 0000 (2008).

342. "The Synthesis of the Oxindole Alkaloid, Alstonisine," Y. Yang, A. Wearing, J. DeChamps, P. LeQuesne and J.M. Cook, J. Nat. Prod., 00, 0000-0000 (2008).