Potential Physiologic Effects of NSAIDS
| Anatomic Region of System | Effects Increased | Effects Decreased |
|---|---|---|
| GI ulceration | X | |
| GI hemorrhage | X | |
| Platelet aggregation | X | |
| Renal Papillary necrosis | X | |
| Interstitial nephritis | X | |
| Prostaglandin function | X | |
| Kinin function | X | |
| Cyclooxygenase (COX) enzymes | X | |
| Liver necrosis | X | |
| Uterine contractions | X | |
| Fetal circulation | X | |
| Fetal abnormalities | X | |
| Cognitive dysfunction | X | |
| Cartilage metabolism | X | |
| Bone fracture healting | X | |
| Bone blood flow | X | |
| Bone and cartilage remodeling | X | |
| Bone ingrowth into implants | X | |
| Soft tissue healing to bone | X | |
| Spinal fusion healing | X |
From the "Journal of the American Association for Laboratory Animal Science", Volume 46, No. 2, March 2007
Updated June 18, 2007 by SAK